Direct condensation of functionalized sp(3) carbons with formanilides for enamine synthesis using an in situ generated HMDS amide catalyst

Chem Commun (Camb). 2014 Jun 21;50(49):6523-5. doi: 10.1039/c4cc02228a. Epub 2014 May 13.

Abstract

The efficient synthesis of functionalized enamines including β-enaminoesters was effectively accomplished by the direct condensation of functionalized sp(3) carbanions such as acetates with formamides using in situ generated HMDS base from catalytic cesium fluoride and stoichiometric tristrimethylsilylamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemical synthesis*
  • Amines / chemistry
  • Carbon / chemistry*
  • Catalysis
  • Formamides / chemistry*
  • Organosilicon Compounds / chemistry*
  • Quantum Theory

Substances

  • Amines
  • Formamides
  • Organosilicon Compounds
  • N-phenylformamide
  • Carbon
  • hexamethylsilazane