Phosphorylated dendronized poly(amido amine)s as protein analogues for directing hydroxylapatite biomineralization

Chem Commun (Camb). 2014 Jun 21;50(49):6491-3. doi: 10.1039/c4cc00617h. Epub 2014 May 12.

Abstract

Dendronized poly(amido amine)s (DPs) bearing tri-phosphate or bis-phosphonate peripheral groups are synthesized. These worm-like DPs can template the formation of BMSCs adhesive hydroxylapatite (HA) on the nano-scale, or self-assemble into mineral-collecting microfibers on the micro-scale, exhibiting similar functions of non-collagenous proteins (NCPs) in the natural biomineralization process of HA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow Cells / cytology
  • Cell Adhesion / drug effects
  • Cell Proliferation / drug effects
  • Dendrimers / chemistry*
  • Durapatite / chemistry*
  • Durapatite / pharmacology
  • Humans
  • Mesenchymal Stem Cells / cytology
  • Nanoparticles / chemistry
  • Phosphorylation
  • Polyamines / chemistry*
  • Proteins / chemistry

Substances

  • Dendrimers
  • Poly(amidoamine)
  • Polyamines
  • Proteins
  • Durapatite