Sodium MRI: methods and applications

Guillaume Madelin; Jae-Seung Lee; Ravinder R Regatte; Alexej Jerschow

doi:10.1016/j.pnmrs.2014.02.001

Sodium MRI: methods and applications

Prog Nucl Magn Reson Spectrosc. 2014 May:79:14-47. doi: 10.1016/j.pnmrs.2014.02.001. Epub 2014 Mar 7.

Authors

Guillaume Madelin¹, Jae-Seung Lee², Ravinder R Regatte¹, Alexej Jerschow³

Affiliations

¹ New York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging, New York, NY 10016, USA.
² New York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging, New York, NY 10016, USA; Chemistry Department, New York University, 100 Washington Square East, New York, NY 10003, USA.
³ Chemistry Department, New York University, 100 Washington Square East, New York, NY 10003, USA. Electronic address: alexej.jerschow@nyu.edu.

Abstract

Sodium NMR spectroscopy and MRI have become popular in recent years through the increased availability of high-field MRI scanners, advanced scanner hardware and improved methodology. Sodium MRI is being evaluated for stroke and tumor detection, for breast cancer studies, and for the assessment of osteoarthritis and muscle and kidney functions, to name just a few. In this article, we aim to present an up-to-date review of the theoretical background, the methodology, the challenges, limitations, and current and potential new applications of sodium MRI.

Keywords: In vivo MRI; Quadrupolar coupling; Relaxation; Sodium MRI; Spherical tensors; –-ATPase.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Ions*
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods
Sodium*

Substances

Ions
Sodium

Abstract

Publication types

MeSH terms

Substances

Grants and funding