Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network

Robert D Simari; Carl J Pepine; Jay H Traverse; Timothy D Henry; Roberto Bolli; Daniel B Spoon; Ed Yeh; Joshua M Hare; Ivonne Hernandez Schulman; R David Anderson; Charles Lambert; Shelly L Sayre; Doris A Taylor; Ray F Ebert; Lemuel A Moyé

doi:10.1161/CIRCRESAHA.114.303720

Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network

Circ Res. 2014 May 9;114(10):1564-8. doi: 10.1161/CIRCRESAHA.114.303720.

Authors

Robert D Simari¹, Carl J Pepine, Jay H Traverse, Timothy D Henry, Roberto Bolli, Daniel B Spoon, Ed Yeh, Joshua M Hare, Ivonne Hernandez Schulman, R David Anderson, Charles Lambert, Shelly L Sayre, Doris A Taylor, Ray F Ebert, Lemuel A Moyé

Affiliation

¹ From Mayo Clinic, Rochester, MN (R.D.S., D.B.S.); University of Florida School of Medicine, Gainesville (C.J.P., R.D.A.); Minneapolis Heart Institute at Abbott Northwestern Hospital, University of Minnesota School of Medicine (J.H.T.); Cedars-Sinai Heart Institute, Los Angeles, CA (T.D.H.); University of Louisville School of Medicine, KY (R.B.); The University of Texas MD Anderson Cancer Center, Houston (E.Y.); University of Miami Miller School of Medicine, FL (J.M.H., I.H.S.); Florida Hospital Tampa Pepin Heart Institute (C.L.); University of Texas Health Science Center School of Public Health, Houston (S.L.S., L.A.M.); Texas Heart Institute, Houston (D.A.T.); and National Heart, Lung, and Blood Institute, Bethesda, MD (R.F.E.).

Abstract

To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implications for future directions in cell therapy for acute myocardial infarction.

Keywords: diagnostic imaging; myocardial infarction; population.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Bone Marrow Transplantation / methods*
Bone Marrow Transplantation / trends
Cell- and Tissue-Based Therapy / methods
Cell- and Tissue-Based Therapy / trends
Clinical Trials as Topic / methods
Clinical Trials as Topic / trends
Databases, Factual / trends
Humans
Leukocytes, Mononuclear / pathology
Leukocytes, Mononuclear / physiology
Leukocytes, Mononuclear / transplantation*
Myocardial Infarction / pathology*
Myocardial Infarction / surgery*
Retrospective Studies
Stroke Volume / physiology
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding