Albumin-micelles via a one-pot technology platform for the delivery of drugs

Yanyan Jiang; Mingtao Liang; Domenic Svejkar; Gene Hart-Smith; Hongxu Lu; Wei Scarano; Martina H Stenzel

doi:10.1039/c4cc00616j

Albumin-micelles via a one-pot technology platform for the delivery of drugs

Chem Commun (Camb). 2014 Jun 18;50(48):6394-7. doi: 10.1039/c4cc00616j.

Authors

Yanyan Jiang¹, Mingtao Liang, Domenic Svejkar, Gene Hart-Smith, Hongxu Lu, Wei Scarano, Martina H Stenzel

Affiliation

¹ Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. M.Stenzel@unsw.edu.au.

PMID: 24811583
DOI: 10.1039/c4cc00616j

Abstract

A new micelle delivery platform based on albumin coated nanoparticles is able to selectively deliver the payload to cancerous cells while healthy cells remain less affected. The technology is simple and can be used in a one-pot procedure.

MeSH terms

Albumins / chemistry*
Albumins / metabolism
Animals
CHO Cells
Cell Line, Tumor
Cell Survival / drug effects
Cricetulus
Curcumin / chemistry*
Curcumin / pharmacology
Drug Carriers / chemistry*
Drug Carriers / pharmacokinetics
Drug Delivery Systems*
Humans
Micelles
Nanoparticles / chemistry*
Particle Size
Polymers / chemistry
Polymers / pharmacokinetics
Structure-Activity Relationship
Surface Properties

Substances

Albumins
Drug Carriers
Micelles
Polymers
Curcumin