Abstract
Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.
Keywords:
afferent pathway; bladder pain syndrome; cytokine; interstitial cystitis; nerve growth factor.
© 2014 The Japanese Urological Association.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Afferent Pathways* / drug effects
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Afferent Pathways* / metabolism
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Afferent Pathways* / physiopathology
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cystitis, Interstitial* / etiology
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Cystitis, Interstitial* / metabolism
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Cystitis, Interstitial* / physiopathology
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Cystitis, Interstitial* / psychology
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Cytokines / metabolism
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Humans
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Inflammation* / metabolism
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Inflammation* / physiopathology
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Lower Urinary Tract Symptoms / physiopathology
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Nerve Growth Factor / metabolism
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Neuronal Plasticity*
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Quality of Life
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Sensory System Agents / pharmacology*
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Therapies, Investigational
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Urethra / innervation
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Urethra / physiopathology
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Urinary Bladder / innervation
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Urinary Bladder / physiopathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Sensory System Agents
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Nerve Growth Factor