Translating glycolytic metabolism to innate immunity in dendritic cells

Cell Metab. 2014 May 6;19(5):737-739. doi: 10.1016/j.cmet.2014.04.012.

Abstract

Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dendritic Cells / immunology*
  • Glycolysis*
  • I-kappa B Kinase / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • T-Lymphocytes / immunology*

Substances

  • Protein Serine-Threonine Kinases
  • I-kappa B Kinase