Abstract
A general and efficient palladium-catalyzed intermolecular direct C-H homocoupling of furans and thiophenes has been developed. The reaction is characterized by using molecular oxygen as the sole oxidant and complete C5-position regioselectivity. Both C2- and C3-substituted furans or thiophenes are appropriate substrates. The approach provides a straightforward, facile, and economical route to bifurans and bithiophenes under mild reaction conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Furans / chemical synthesis
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Furans / chemistry*
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Heterocyclic Compounds, 2-Ring / chemical synthesis*
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Heterocyclic Compounds, 2-Ring / chemistry
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Molecular Structure
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Oxidants / chemistry*
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Oxygen / chemistry*
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Palladium / chemistry*
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Thiophenes / chemical synthesis
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Thiophenes / chemistry*
Substances
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Furans
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Heterocyclic Compounds, 2-Ring
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Oxidants
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Thiophenes
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Palladium
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Oxygen