Abstract
We describe a practical, large-scale synthesis of the "fairy-ring" plant-growth regulator 2-azahypoxanthine (AHX), and its biologically active hydroxyl metabolite (AOH) and riboside derivative (AHXr). AHXr, a biosynthetic intermediate, was synthesized from inosine via a biomimetic route. Biotinylated derivatives of AHX and AHXr were also synthesized as probes for mechanistic studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry
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Azides / chemistry
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Biotin / chemistry*
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Chemistry, Organic / methods*
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Hypoxanthines / chemical synthesis*
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Hypoxanthines / chemistry
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Plant Growth Regulators / chemical synthesis*
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Plant Growth Regulators / chemistry
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Staining and Labeling*
Substances
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Alkynes
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Azides
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Hypoxanthines
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Plant Growth Regulators
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Biotin
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2-azahypoxanthine