Daptomycin-induced rhabdomyolysis and acute liver injury

Scand J Infect Dis. 2014 Jul;46(7):537-40. doi: 10.3109/00365548.2014.901555. Epub 2014 May 7.

Abstract

Daptomycin use is a known cause of rhabdomyolysis; its role in liver injury is less certain. We report a case of daptomycin-induced rhabdomyolysis with liver injury. This report indicates a role for liver function monitoring while receiving daptomycin, as well as the importance of promptly considering drug toxicities in acute and emergency care settings.

Keywords: Daptomycin; drug-induced; hepatotoxicity; obese; rhabdomyolysis; statin.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections / drug therapy
  • Chemical and Drug Induced Liver Injury / diagnosis*
  • Daptomycin / adverse effects*
  • Daptomycin / therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / diagnosis*

Substances

  • Anti-Bacterial Agents
  • Daptomycin