HPV infections among MSM in Shenzhen, China

PLoS One. 2014 May 6;9(5):e96364. doi: 10.1371/journal.pone.0096364. eCollection 2014.

Abstract

Background: An increasing incidence of anal cancer among men, especially men who have sex with men (MSM) suggests a need to better understand anal human papillomavirus (HPV) infection among this group.

Methods: A cross-sectional study was conducted among MSM in Shenzhen, China. Blood was collected for HIV serological testing and syphilis serological screening, and anal swabs were collected for HPV genotyping. Difference of HPV prevalence between HIV seropositive and HIV seronegative MSM was assessed by chi-square test. Factors associated with anal canal HPV infection were assessed by univariate and multivariate logistic regression.

Results: A total of 408 MSM were recruited. HIV and HPV prevalence were 6.9% and 36.4%, respectively. HPV was detected in the anal canal in 71.4% of the HIV-positive MSM and in 33.8% of the HIV-negative MSM (P<0.001). Oncogenic types were seen more often in anal specimens of HIV-positive MSM than in specimens of HIV-negative MSM (P = 0.001). The HPV genotypes detected most frequently were HPV06 (8.2%), HPV16 (7.2%), HPV11 (6.4%), HPV18 (4.7%), HPV58 (4.7%), and HPV52 (4.2%).

Conclusions: In this study, HIV positive MSM had a higher burden of HPV infection, especially oncogenic HPV infection. HPV types 52 and 58 were as popular as those types designed for the currently available vaccine (HPV6, 11, 16, 18).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anal Canal / virology
  • Anus Neoplasms / virology
  • China / epidemiology
  • Cross-Sectional Studies
  • Genotype
  • HIV Infections / virology
  • HIV Seropositivity / genetics
  • Homosexuality, Male
  • Humans
  • Male
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology
  • Prevalence
  • Sexual Behavior
  • Young Adult

Grants and funding

The study was supported by a grant from the Mega Project of China National Science Research for the 11th Five-Year Plan (2008ZX10001–005). Additional funding was received from National science and technology major special project- jiangsu provincial demonstration project on infectious diseases control and prevention (Grant No:2009ZX10004–904). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.