An analogue front-end model for developing neural spike sorting systems

IEEE Trans Biomed Circuits Syst. 2014 Apr;8(2):216-27. doi: 10.1109/TBCAS.2014.2313087. Epub 2014 Apr 28.

Abstract

In spike sorting systems, front-end electronics is a crucial pre-processing step that not only has a direct impact on detection and sorting accuracy, but also on power and silicon area. In this work, a behavioural front-end model is proposed to assess the impact of the design parameters (including signal-to-noise ratio, filter type/order, bandwidth, converter resolution/rate) on subsequent spike processing. Initial validation of the model is provided by applying a test stimulus to a hardware platform and comparing the measured circuit response to the expected from the behavioural model. Our model is then used to demonstrate the effect of the Analogue Front-End (AFE) on subsequent spike processing by testing established spike detection and sorting methods on a selection of systems reported in the literature. It is revealed that although these designs have a wide variation in design parameters (and thus also circuit complexity), the ultimate impact on spike processing performance is relatively low (10-15%). This can be used to inform the design of future systems to have an efficient AFE whilst also maintaining good processing performance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Basal Ganglia / physiology
  • Brain / physiology*
  • Brain-Computer Interfaces*
  • Epilepsy / physiopathology
  • Haplorhini
  • Humans
  • Models, Neurological*
  • Neocortex / physiology
  • Neurons
  • Signal Processing, Computer-Assisted*