We have recently identified that the ligand of natural cytotoxicity triggering receptor 2 (NCR2, best known as NKp44) is expressed on a large panel of malignant cells. This ligand provides a new tool to investigate how stressed cells are recognized and eliminated by natural killer (NK) cells, and to develop novel immunotherapeutic paradigms against cancer.
Keywords: MLL5; NKp44; NKp44L; immunotherapy; natural cytotoxicity receptors; natural killer cells; tumor cells.