Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls

Wei Chen; Xueyao Liu; Yun Xiao; Yanhong Chen; Guangchuan Wang; Cuilian Liu; Xurong Xu; Ruikang Tang

doi:10.1002/smll.201303849

Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls

Small. 2014 Sep 24;10(18):3644-9. doi: 10.1002/smll.201303849. Epub 2014 May 5.

Authors

Wei Chen¹, Xueyao Liu, Yun Xiao, Yanhong Chen, Guangchuan Wang, Cuilian Liu, Xurong Xu, Ruikang Tang

Affiliation

¹ Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.

PMID: 24799417
DOI: 10.1002/smll.201303849

Abstract

Controllable biomineralization modification of cisplatin can alter the drug biodistribution with extended circulation time in blood. These changes increase passive tumor target and decrease non-specific accumulation significantly, which can improve chemotherapeutic effect with minimum side effects.

Keywords: biodistribution; biomineralization; cisplatin; nanoparticles; size effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Cell Line, Tumor
Cisplatin / administration & dosage*
Drug Carriers
Endocytosis
Humans
Lysosomes / metabolism
Male
Mice
Mice, Nude
Microscopy, Electron, Transmission
Nanomedicine / methods*
Nanoparticles / chemistry
Neoplasm Transplantation
Particle Size
Tissue Distribution

Substances

Antineoplastic Agents
Drug Carriers
Cisplatin