Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism

J L Del Pozo; N Fernández-Ros; E Sáez; J I Herrero; J R Yuste; J M Banales

doi:10.1128/AAC.02856-14

Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism

Antimicrob Agents Chemother. 2014 Jul;58(7):4227-9. doi: 10.1128/AAC.02856-14. Epub 2014 May 5.

Authors

J L Del Pozo¹, N Fernández-Ros², E Sáez³, J I Herrero⁴, J R Yuste², J M Banales⁵

Affiliations

¹ Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain jdelpozo@unav.es.
² Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
³ Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain.
⁴ Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
⁵ Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of Basque Country (UPV), IKERBASQUE (Basque Foundation for Science), San Sebastián, Spain.

Abstract

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.

Publication types

Case Reports

MeSH terms

Acetamides / adverse effects*
Acetamides / therapeutic use
Acidosis, Lactic / chemically induced*
Acidosis, Lactic / therapy
Adult
Aged
DNA, Mitochondrial / genetics*
Female
Genetic Predisposition to Disease
Humans
Linezolid
Liver Transplantation
Male
Mitochondria / genetics*
Nocardia Infections / drug therapy
Nocardia asteroides / drug effects
Oxazolidinones / adverse effects*
Oxazolidinones / therapeutic use
Polymorphism, Single Nucleotide
RNA, Ribosomal, 16S / genetics
Tuberculosis, Pulmonary / drug therapy

Substances

Acetamides
DNA, Mitochondrial
Oxazolidinones
RNA, Ribosomal, 16S
Linezolid