Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China

Arch Virol. 2014 Sep;159(9):2497-502. doi: 10.1007/s00705-014-2067-6. Epub 2014 May 6.

Abstract

To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • China / epidemiology
  • Cluster Analysis
  • Communicable Diseases, Emerging / epidemiology
  • Communicable Diseases, Emerging / virology*
  • Enterovirus / classification*
  • Enterovirus / genetics*
  • Enterovirus / isolation & purification
  • Female
  • Genotype
  • Hand, Foot and Mouth Disease / epidemiology
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Infant
  • Male
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics*
  • Recombination, Genetic
  • Sequence Analysis, DNA
  • Viral Structural Proteins / genetics

Substances

  • RNA, Viral
  • Viral Structural Proteins

Associated data

  • GENBANK/KF422142
  • GENBANK/KF422143
  • GENBANK/KF422144
  • GENBANK/KF422145
  • GENBANK/KF422146
  • GENBANK/KF422147