Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta

Mar Drugs. 2014 Apr 30;12(5):2446-57. doi: 10.3390/md12052446.

Abstract

New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Neutrophil Infiltration / drug effects
  • Taiwan

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Diterpenes
  • eunicellin