Male fertility preservation, where are we in 2014?

Ann Endocrinol (Paris). 2014 May;75(2):115-7. doi: 10.1016/j.ando.2014.03.011. Epub 2014 Apr 29.

Abstract

Male fertility preservation receives growing attention in the field of reproductive medicine. The first clinical programs were established to preserve reproductive potential in men needing gonadotoxic treatment. Sperm cryopreservation is now a standard procedure. Since a few years, several centres offer testicular tissue cryopreservation to prepubertal boys. This method is still experimental and further research is needed to implement the transplantation techniques in the clinic. With the aim to preserve or restore fertility in patients affected by other diseases (Klinefelter syndrome, Sertoli cell only syndrome), techniques for in vitro spermatogenesis are being developed.

Keywords: Cellules souches spermatogoniales; Fertility preservation; Gonadotoxic treatment; Klinefelter; La préservation de la fertilité; Le traitement gonadotoxique; Spermatogenesis; Spermatogenèse; Spermatogonial stem cell.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult Stem Cells / transplantation
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Autografts
  • Child
  • Cryopreservation / methods
  • Fertility Preservation / methods*
  • Fertility Preservation / trends
  • Humans
  • Infertility, Male / etiology
  • Klinefelter Syndrome / complications
  • Male
  • Sertoli Cell-Only Syndrome / complications
  • Sperm Banks
  • Sperm Retrieval
  • Spermatogenesis
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / drug therapy
  • Testis / transplantation

Substances

  • Antineoplastic Agents