Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways

Kunio Doi; Koji Uetsuka

doi:10.1293/tox.2013-0062

Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways

J Toxicol Pathol. 2014 Apr;27(1):1-10. doi: 10.1293/tox.2013-0062. Epub 2014 Apr 30.

Authors

Kunio Doi¹, Koji Uetsuka²

Affiliations

¹ Bozo Research Center Inc., 8 Ohkubo, Tsukuba, Ibaraki 300-2611, Japan ; Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
² Animal Health Laboratory, College of Agriculture, Ibaraki University, 3-21-1, Ami-machi, Inashiki-gun, Ibaraki 300-0393, Japan.

Abstract

Among the many mycotoxins, T-2 toxin, citrinin (CTN), patulin (PAT), aflatoxin B1 (AFB1) and ochratoxin A (OTA) are known to have the potential to induce dermal toxicity and/or tumorigenesis in rodent models. T-2 toxin, CTN, PAT and OTA induce apoptosis in mouse or rat skin. PAT, AFB1 and OTA have tumor initiating properties, and OTA is also a tumor promoter in mouse skin. This paper reviews the molecular mechanisms of dermal toxicity and tumorigenesis induced in rodent models by these mycotoxins especially from the viewpoint of oxidative stress-mediated pathways.

Keywords: T-2 toxin; aflatoxin B1; citrinin; dermal toxicity; dermal tumorigenesis; ochratoxin A; patulin.

Publication types

Review