Acyclic sulfides, garlicnins L-1-L-4, E, and F, from Allium sativum

Chem Pharm Bull (Tokyo). 2014;62(5):477-82. doi: 10.1248/cpb.c14-00003.

Abstract

Six novel acyclic sulfides, named garlicnins L-1-L-4 (1-4), E (5), and F (6), were isolated from the acetone extracts, with the ability to suppress M2 macrophage activation, of the bulbs of garlic (Allium sativum L.), and their chemical structures were characterized.

MeSH terms

  • Garlic / chemistry*
  • Humans
  • Macrophages / drug effects*
  • Molecular Structure
  • Structure-Activity Relationship
  • Sulfides / chemistry
  • Sulfides / isolation & purification
  • Sulfides / pharmacology*
  • Thiophenes / chemistry
  • Thiophenes / isolation & purification
  • Thiophenes / pharmacology*

Substances

  • Sulfides
  • Thiophenes