Phosphate esters and anhydrides--recent strategies targeting nature's favoured modifications

Org Biomol Chem. 2014 Jun 14;12(22):3526-30. doi: 10.1039/c4ob00478g. Epub 2014 Apr 30.

Abstract

Esters and anhydrides of phosphoric acid are essential in biology. It is very difficult to identify processes in life that do not involve these modifications and their transformation at some point. Consequently, phosphorylation chemistry is an essential methodology with significant impact on the biological sciences. This perspective gives an overview of some very recent achievements in synthetic phosphorylation chemistry and aims at identifying challenges that lie ahead.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anhydrides / chemical synthesis
  • Anhydrides / chemistry*
  • Deoxyguanine Nucleotides / chemical synthesis
  • Deoxyguanine Nucleotides / chemistry
  • Esters / chemistry*
  • Phosphates / chemical synthesis*
  • Phosphates / chemistry
  • Uridine Diphosphate / chemical synthesis
  • Uridine Diphosphate / chemistry
  • Uridine Monophosphate / chemistry

Substances

  • Anhydrides
  • Deoxyguanine Nucleotides
  • Esters
  • Phosphates
  • Uridine Diphosphate
  • deoxyguanosine triphosphate
  • Uridine Monophosphate