Myrotheciumones: bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens

Ting Lin; Guanghui Wang; Wenjun Shan; Dequan Zeng; Rong Ding; Xin Jiang; Dan Zhu; Xiaoxuan Liu; Shuiyuan Yang; Haifeng Chen

doi:10.1016/j.bmcl.2014.04.016

Myrotheciumones: bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2504-7. doi: 10.1016/j.bmcl.2014.04.016. Epub 2014 Apr 13.

Authors

Affiliations

¹ School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China. Electronic address: linting@xmu.edu.cn.
² School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.
³ School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China. Electronic address: haifeng@xmu.edu.cn.

PMID: 24775302
DOI: 10.1016/j.bmcl.2014.04.016

Abstract

Two new bicyclic lactones, myrotheciumones A (1) and B (2) which possessed a rare ring-fusion system were isolated from Myrothecium roridum (M. roridum), an endophytic fungus of the medicinal herb plant Ajuga decumbens (A. decumbens) via an in vitro cytotoxicity assay. Structures were deduced from 1D and 2D NMR (Nuclear magnetic resonance) data. Myrotheciumone A's in vitro cytotoxicity and apoptotic activity were evaluated and myrotheciumone A was shown to exert cytotoxicity via inducing apoptosis in cancer cell line.

Keywords: Ajuga decumbens; Apoptosis; Cytotoxicity; Endophytic fungus; Myrotheciumones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ajuga / microbiology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Ascomycota / chemistry*
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Lactones / chemistry
Lactones / isolation & purification
Lactones / pharmacology*
Molecular Structure
Structure-Activity Relationship

Substances

Antineoplastic Agents
Bridged Bicyclo Compounds, Heterocyclic
Lactones
myrotheciumone A