Mother-to-child transmission of Trypanosoma cruzi infection (Chagas disease): a neglected problem

Abstract

Congenital Chagas disease may be considered a global health problem and the underdiagnosis of congenital infections should be a matter of concern. Vertical transmission is an important mode of transmission of Trypanosoma cruzi infection in non-endemic areas. Treatment in the early phases of the infection can prevent progression of the disease and is curative in the majority of cases. Prevention strategies should focus on early detection and treatment of congenital cases, screening at-risk women during pregnancy and treatment of non-pregnant women of childbearing age. Management of congenital Chagas disease and T. cruzi infection during pregnancy is discussed.

Keywords: Chagas disease; Congenital; Neglected disease; Pregnancy; Trypanosoma cruzi.