Specific effects of chondroitin sulfate-modified hyaluronidase on the function of progenitor cells

G N Zyuz'kov; A V Maksimenko; V V Zhdanov; E V Udut; A D Turashev; L A Miroshnichenko; E V Simanina; A V Chaikovskii; M Yu Minakova; A V Artamonov; A A Bekarev; P G Madonov; V V Udut; A M Dygai

doi:10.1007/s10517-014-2393-4

Specific effects of chondroitin sulfate-modified hyaluronidase on the function of progenitor cells

Bull Exp Biol Med. 2014 Feb;156(4):544-7. doi: 10.1007/s10517-014-2393-4. Epub 2014 Mar 5.

Authors

G N Zyuz'kov¹, A V Maksimenko, V V Zhdanov, E V Udut, A D Turashev, L A Miroshnichenko, E V Simanina, A V Chaikovskii, M Yu Minakova, A V Artamonov, A A Bekarev, P G Madonov, V V Udut, A M Dygai

Affiliation

¹ Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.

PMID: 24771446
DOI: 10.1007/s10517-014-2393-4

Abstract

We have demonstrated the possibility of stimulation of the function of various types of precursor cells with hyaluronidase modified with chondroitin sulfate. Parenteral administration of modified hyaluronidase increased the number of fibroblast, granulomonocyte, and erythroid CFU in the hemopoietic tissue. The changes in the pool of mesenchymal progenitor cells were more pronounced in comparison with those induced by native enzyme.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Marrow Cells / drug effects
Bone Marrow Cells / physiology*
Cell Adhesion
Cell Count
Chondroitin Sulfates / chemistry*
Female
Hyaluronoglucosaminidase / chemistry
Hyaluronoglucosaminidase / pharmacology*
Male
Mice, Inbred CBA
Regenerative Medicine
Stem Cells / drug effects
Stem Cells / physiology*

Substances

Chondroitin Sulfates
Hyaluronoglucosaminidase