Pluronics suppress association of low-density lipoproteins inducing atherogenesis

A A Mel'nichenko; D V Aksenov; O M Panasenko; A A Yaroslavov; I A Sobenin; A N Orehov

doi:10.1007/s10517-014-2412-5

Pluronics suppress association of low-density lipoproteins inducing atherogenesis

Bull Exp Biol Med. 2014 Mar;156(5):631-4. doi: 10.1007/s10517-014-2412-5. Epub 2014 Mar 25.

Authors

A A Mel'nichenko¹, D V Aksenov, O M Panasenko, A A Yaroslavov, I A Sobenin, A N Orehov

Affiliation

¹ Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, inat-science@yandex.ru.

PMID: 24770745
DOI: 10.1007/s10517-014-2412-5

Abstract

We studied the effect of pluronics P85, L61, and F68 with different hydrophilic-lipophilic characteristics on association of LDL. It was found that pluronics with pronounced hydrophobic properties (P85 and L61) in concentrations close to or surpassing the critical concentration of micelle formation inhibited LDL association, while hydrophilic pluronic F68 in all concentrations had no effect on LDL association.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Atherosclerosis / blood
Atherosclerosis / drug therapy
Carotid Artery Diseases / blood
Carotid Artery Diseases / drug therapy
Drug Evaluation, Preclinical
Humans
Hydrophobic and Hydrophilic Interactions
Kinetics
Lipoproteins, LDL / blood
Lipoproteins, LDL / chemistry*
Male
Middle Aged
Particle Size
Poloxamer / chemistry*

Substances

Lipoproteins, LDL
Poloxamer