From endosomes to the trans-Golgi network

Lei Lu; Wanjin Hong

doi:10.1016/j.semcdb.2014.04.024

From endosomes to the trans-Golgi network

Semin Cell Dev Biol. 2014 Jul:31:30-9. doi: 10.1016/j.semcdb.2014.04.024. Epub 2014 Apr 23.

Authors

Lei Lu¹, Wanjin Hong²

Affiliations

¹ School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: lulei@ntu.edu.sg.
² Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; School of Pharmaceutical Sciences, Xiamen University, Xiamen, People's Republic of China.

PMID: 24769370
DOI: 10.1016/j.semcdb.2014.04.024

Abstract

The retrograde trafficking from endosomes to the trans-Golgi network (TGN) is one of the major endocytic pathways to divert proteins and lipids away from lysosomal degradation. Retrograde transported cargos enter the TGN via two itineraries from either the early endosome/recycling endosome or the late endosome and involve various machinery components such as retromer, sorting nexins, clathrin, small GTPases, tethering factors and SNAREs. Recently, the pathway has been recognized for its role in signal transduction, physiology and pathogenesis of human diseases.

Keywords: Endosome; Retrograde membrane trafficking; Retromer; Trans-Golgi network.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Endosomes / metabolism*
Humans
Neurodegenerative Diseases / metabolism
Signal Transduction
trans-Golgi Network / metabolism*