PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance

Trends Microbiol. 2014 Jul;22(7):379-88. doi: 10.1016/j.tim.2014.03.009. Epub 2014 Apr 23.

Abstract

The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second messenger phosphatidylinositol 4,5-biphosphate (PIP2), an important regulator of actin organization. PIP2 production is induced by HIV-1 attachment and facilitates viral infection. However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. This review examines recent reports describing the roles played by actin-adaptor proteins during HIV-1 infection of CD4+ T cells, highlighting the influence of the signaling lipid PIP2 in this process.

Keywords: HIV-1; PIP(2); actin-binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism*
  • Adaptor Proteins, Signal Transducing / metabolism*
  • CD4-Positive T-Lymphocytes / physiology*
  • CD4-Positive T-Lymphocytes / virology*
  • HIV-1 / physiology*
  • Humans
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*
  • Protein Multimerization
  • Virus Internalization*

Substances

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Phosphatidylinositol 4,5-Diphosphate