Abstract
Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed osteoclast differentiation inhibitory activity in a dose dependent manner.
Keywords:
Activity; Alkaloids; Chrotacumines; Dysoxylum; Meliaceae.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Cell Differentiation / drug effects
-
Chromones / chemistry
-
Chromones / isolation & purification
-
Chromones / pharmacology*
-
Dose-Response Relationship, Drug
-
Humans
-
Meliaceae / chemistry*
-
Molecular Structure
-
Osteoclasts / cytology
-
Osteoclasts / drug effects*
-
Piperidines / chemistry
-
Piperidines / isolation & purification
-
Piperidines / pharmacology*
-
Plant Bark / chemistry
-
Structure-Activity Relationship
Substances
-
Alkaloids
-
Chromones
-
Piperidines
-
chrotacumine G
-
chrotacumine J