Chrotacumines G-J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2437-9. doi: 10.1016/j.bmcl.2014.04.020. Epub 2014 Apr 13.

Abstract

Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed osteoclast differentiation inhibitory activity in a dose dependent manner.

Keywords: Activity; Alkaloids; Chrotacumines; Dysoxylum; Meliaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Cell Differentiation / drug effects
  • Chromones / chemistry
  • Chromones / isolation & purification
  • Chromones / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Meliaceae / chemistry*
  • Molecular Structure
  • Osteoclasts / cytology
  • Osteoclasts / drug effects*
  • Piperidines / chemistry
  • Piperidines / isolation & purification
  • Piperidines / pharmacology*
  • Plant Bark / chemistry
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Chromones
  • Piperidines
  • chrotacumine G
  • chrotacumine J