The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

Cell Mol Biol Lett. 2014 Jun;19(2):243-8. doi: 10.2478/s11658-014-0193-5. Epub 2014 Apr 24.

Abstract

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds - 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid - to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism*
  • Carboxylic Acids / chemistry*
  • Dendrimers / chemistry
  • Dendrimers / pharmacology*
  • Electrophysiological Phenomena / drug effects
  • Excitatory Postsynaptic Potentials / drug effects
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Hypoxia*
  • In Vitro Techniques
  • Isoxazoles / chemistry*
  • Male
  • Oxygen / metabolism
  • Rats
  • Urea / analogs & derivatives*
  • Urea / chemistry

Substances

  • 1-(6-hydroxyhexyl)-3-(5-phenylisoxazole-3-yl)urea
  • 5-phenylisoxazole-3-carboxylic acid
  • Carboxylic Acids
  • Dendrimers
  • Isoxazoles
  • PAMAM Starburst
  • Urea
  • Oxygen