Lung cancer is one of the most common malignant tumor in the world, severely threatening human life. Recently, targeted therapy such as the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) made huge progress in treatment of lung cancer. EGFR-TKIs, with its high selectivity and low toxicity, is the first choice for EGFR-mutated patients in stage IV non-small cell lung cancer (NSCLC). However, secondary drug resistance becomes a clinical problem to be urgently resolved. In recent years, a series of preclinical studies showed that EGFR-TKI can enhance the antitumor activity of ionizing radiation. Therefore, EGFR-TKI combined with radiation is extremely promising therapy pattern for advanced NSCLC. This review will discuss the research status in EGFR-TKI and radiotherapy for advanced NSCLC.
肺癌是全球最常见的恶性肿瘤之一，严重威胁人类生命。近年来，以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor tyrosine kinase inhibitors, EGFR-TKIs）为首的靶向药物在肺癌治疗中取得巨大进展。因其具有高选择性和低毒性的优势，目前已成为IV期非小细胞肺癌（non-small cell lung cancer, NSCLC）EGFR突变患者的一线治疗方案。然而随着临床的广泛应用，继发耐药成为临床亟待解决的问题。近年来，基础研究证实，EGFR-TKI具有放射增敏性，理论上二者联合不但可以解决放疗后期肿瘤的放射抵抗以及EGFR-TKI继发耐药，还可以增加对肿瘤杀伤能力，同时副反应较同步放化疗小。因此，EGFR-TKI与放疗联合成为晚期NSCLC（IIIb期/IV期）极具探索的治疗模式。本文就EGFR-TKI与放疗联合治疗晚期NSCLC的基础与临床研究进展进行综述。