Enantioselective synthesis in carbohydrate-based drug discovery: imino sugars, alkaloids and macrolide antibiotics

Curr Top Med Chem. 2014;14(10):1235-43. doi: 10.2174/1568026614666140423103848.

Abstract

This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Carbohydrates / chemical synthesis*
  • Carbohydrates / chemistry
  • Chemistry Techniques, Synthetic*
  • Drug Discovery*
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Carbohydrates
  • Macrolides