EPR imaging of dose distributions aiming at applications in radiation therapy

Radiat Prot Dosimetry. 2014 Jun;159(1-4):130-6. doi: 10.1093/rpd/ncu142. Epub 2014 Apr 21.

Abstract

A one-dimensional electron paramagnetic resonance (EPR) imaging method for visualisation of dose distributions in photon fields has been developed. Pressed pellets of potassium dithionate were homogeneously irradiated in a (60)Co radiation field to 600 Gy. The EPR analysis was performed with an X-Band (9.6 GHz) Bruker E540 EPR and EPR imaging spectrometer equipped with an E540 GC2X two-axis X-band gradient coil set with gradients along the y axis (along the sample tube) and z axis (along B0) and an ER 4108TMHS resonator. Image reconstruction, including deconvolution, baseline corrections and corrections for the resonator sensitivity, was performed using an in-house-developed Matlab code for the purpose to have a transparent and complete algorithm for image reconstruction. With this method, it is possible to visualise a dose distribution with an accuracy of ∼5 % within ±5 mm from the centre of the resonator.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brachytherapy*
  • Cobalt Radioisotopes*
  • Electron Spin Resonance Spectroscopy / methods*
  • Humans
  • Image Enhancement / methods*
  • Radiation Dosage
  • Radiometry / methods*
  • Thiones / chemistry
  • Thiones / radiation effects*

Substances

  • Cobalt Radioisotopes
  • Thiones