Total synthesis of (+)-kopsihainanine A

Chem Commun (Camb). 2014 Jun 1;50(43):5782-5. doi: 10.1039/c4cc01843e. Epub 2014 Apr 22.

Abstract

Total synthesis of (+)-kopsihainanine A was accomplished on the basis of (i) Stoltz's enantioselective decarboxylative asymmetric allylation and (ii) the proposed biogenetic pathway from the related alkaloid, kopsihainanine B. In addition, HPLC analysis of the synthetic (+)-kopsihainanine A confirmed its ee to be 99% with [α] = 25.35.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry Techniques, Synthetic
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Heterocyclic Compounds, 4 or More Rings
  • kopsihainanine A