The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

Harikrishna Reddy R; Hackyoung Kim; Kwangmo Noh; Young Jun Kim

doi:10.5483/bmbrep.2014.47.4.060

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

BMB Rep. 2014 Apr;47(4):192-6. doi: 10.5483/bmbrep.2014.47.4.060.

Authors

Harikrishna Reddy R¹, Hackyoung Kim¹, Kwangmo Noh², Young Jun Kim³

Affiliations

¹ Departments of Applied Biochemistry Research Center, Konkuk University, Chungju 380-701, Korea.
² Departments of Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.
³ Departments of Applied Biochemistry and Nanotechnology Research Center, Konkuk University, Chungju 380-701, Korea.

Abstract

RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases are a newly emerging family of phosphatases that are members of DXDX (T/V). The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP. Extensive study of SCP1 has elicited the diversified roles of the small C terminal domain phosphatase. The SCP1 plays a vital role in various biological activities, like neuronal gene silencing and preferential Ser5 dephosphorylation, acts as a cardiac hypertrophy inducer with the help of its intronic miRNAs, and has shown a key role in cell cycle regulation. This short review offers an explanation of the mechanism of action of small CTD phosphatases, in different biological activities and metabolic processes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Phosphoprotein Phosphatases / metabolism*
Protein Structure, Tertiary
RNA Polymerase II / chemistry*
RNA Polymerase II / metabolism*
Signal Transduction

Substances

RNA Polymerase II
Phosphoprotein Phosphatases
carboxy-terminal domain phosphatase