A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats

Nobuhiro Nagai; Hirokazu Kaji; Hideyuki Onami; Yuki Katsukura; Yumi Ishikawa; Zhaleh Kashkouli Nezhad; Kaori Sampei; Satoru Iwata; Shuntaro Ito; Matsuhiko Nishizawa; Toru Nakazawa; Noriko Osumi; Yukihiko Mashima; Toshiaki Abe

doi:10.1002/adhm.201400114

A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats

Adv Healthc Mater. 2014 Oct;3(10):1555-60, 1524. doi: 10.1002/adhm.201400114. Epub 2014 Apr 19.

Authors

Nobuhiro Nagai¹, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe

Affiliation

¹ Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

PMID: 24753450
DOI: 10.1002/adhm.201400114

Abstract

Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

Keywords: edaravone; poly(ethyleneglycol) dimethacrylate; retina; transscleral drug delivery; unoprostone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Ophthalmic
Animals
Antipyrine / administration & dosage
Antipyrine / analogs & derivatives
Antipyrine / pharmacokinetics
Dinoprost / administration & dosage
Dinoprost / analogs & derivatives
Dinoprost / pharmacokinetics
Drug Combinations
Drug Delivery Systems / instrumentation*
Drug Delivery Systems / methods*
Edaravone
Equipment Design
Methacrylates / chemistry
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / pharmacokinetics
Polyethylene Glycols / chemistry
Polymethacrylic Acids / chemistry
Prostheses and Implants
Rats
Retina / metabolism*
Retina / radiation effects
Retinal Diseases / drug therapy*
Retinal Diseases / etiology
Retinal Diseases / metabolism
Retinal Diseases / prevention & control
Sclera / surgery

Substances

Drug Combinations
Methacrylates
Neuroprotective Agents
Polymethacrylic Acids
poly(ethylene glycol)-dimethacrylate
triethylene glycol dimethacrylate
Polyethylene Glycols
isopropyl unoprostone
Dinoprost
Edaravone
Antipyrine