Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Chem Commun (Camb). 2014 Jun 1;50(43):5741-4. doi: 10.1039/c4cc02011a. Epub 2014 Apr 22.

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / chemistry*
  • Animals
  • Brain / metabolism*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Mice
  • Models, Molecular
  • Peptide Fragments / chemistry*
  • Protein Multimerization*
  • Protein Structure, Secondary
  • Spectrometry, Fluorescence
  • Water / chemistry

Substances

  • Amyloid beta-Peptides
  • Fluorescent Dyes
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • Water