Abstract
We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid beta-Peptides / chemistry*
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Animals
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Brain / metabolism*
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Fluorescent Dyes / chemistry*
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HeLa Cells
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Humans
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Mice
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Models, Molecular
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Peptide Fragments / chemistry*
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Protein Multimerization*
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Protein Structure, Secondary
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Spectrometry, Fluorescence
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Water / chemistry
Substances
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Amyloid beta-Peptides
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Fluorescent Dyes
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Peptide Fragments
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amyloid beta-protein (1-42)
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Water