The role of the transcription factor KLF2 in vascular development and disease

Prog Mol Biol Transl Sci. 2014:124:155-88. doi: 10.1016/B978-0-12-386930-2.00007-0.

Abstract

The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of processes during development and disease such as endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation. In this review, we summarize the current understanding about KLF2 with a focus on its effects on vascular biology.

Keywords: Angiogenesis; Atherosclerosis; Endothelium; KLF2; Shear stress; Valvulogenesis; Vasculogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Vessels / embryology*
  • Blood Vessels / metabolism*
  • Hemorheology
  • Humans
  • Kruppel-Like Transcription Factors / metabolism*
  • Mechanotransduction, Cellular
  • Models, Biological
  • Vascular Diseases / metabolism*
  • Vascular Diseases / pathology

Substances

  • Kruppel-Like Transcription Factors