Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer

Zesheng Lv; Longlong Chang; Xingwen Long; Jianping Liu; Yuzhang Xiang; Jinjian Liu; Jianfeng Liu; Hongzhang Deng; Liandong Deng; Anjie Dong

doi:10.1016/j.carbpol.2014.03.016

Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer

Carbohydr Polym. 2014 Aug 8:108:26-33. doi: 10.1016/j.carbpol.2014.03.016. Epub 2014 Mar 21.

Authors

Affiliations

¹ Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
² Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 300072, China.
³ Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. Electronic address: dengliandong@tju.edu.cn.
⁴ Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.

PMID: 24751243
DOI: 10.1016/j.carbpol.2014.03.016

Abstract

In this work, a new hydrogel was constructed using poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) tri-block copolymers (PECT) with hyaluronic acid (HA) in order to expand application scopes of PECT hydrogel. The rheological and sol-gel phase transition behaviors were investigated by rheometer and test tube inversion method, and the interior morphologies of hydrogel systems were observed by scanning electron microscope (SEM). With the introduction of HA, certain properties of PECT hydrogel, such as viscosity and morphology, have present trends with regularity. Furthermore, with the participation of HA, the degradation and release of acetylsalicylic acid was slightly affected, however, the drug release mechanism of hydrogel has not been changed. PECT/HA hydrogel is confirmed to be non-toxic through a test to NIH3T3 cells. In conclusion, blending with HA is a feasible and safe method to tune properties of PECT hydrogel.

Keywords: Degradation; Drug release; Hyaluronic acid; Hybrid; Hydrogel; Poly(ɛ-caprolactone)/poly(ethylene glycol) block copolymer.

Publication types

Research Support, Non-U.S. Gov't