Abstract
The Stewartia koreana Nakai (SK) had been used in oriental traditional medicine as a remedy for acute gastroenteritis, liver diseases, quadriplegia and pain. The antioxidant activity guided isolation 80% methyl extract from stems of SK yielded eight phenolic compounds. We evaluated the anti-oxidative and anti-inflammatory effects of these compounds via assays of 1,1-diphenyl-2-picrylhydazyl (DPPH) radicals and inhibition of nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. The results demonstrated that syringaresinol (6) exhibited significant DPPH radical-scavenging activity and inhibitory effects on NO production compared with its positive controls, ascorbic acid and L-NMMA, respectively.
Keywords:
Stewartia koreana; antioxidants; nitric oxide; radical scavengers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Ascorbic Acid / pharmacology
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Biphenyl Compounds / pharmacology*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology*
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Oxidation-Reduction
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology*
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Picrates / pharmacology*
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Plant Stems / chemistry
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Theaceae / chemistry*
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omega-N-Methylarginine / pharmacology
Substances
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Anti-Inflammatory Agents
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Antioxidants
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Biphenyl Compounds
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Free Radical Scavengers
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Furans
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Lignans
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Lipopolysaccharides
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Phenols
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Picrates
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syringaresinol
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omega-N-Methylarginine
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Nitric Oxide
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1,1-diphenyl-2-picrylhydrazyl
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Ascorbic Acid