Monoterpenes from the fruits of Amomum kravanh

J Asian Nat Prod Res. 2014;16(5):471-5. doi: 10.1080/10286020.2014.906405. Epub 2014 Apr 22.

Abstract

Two new monoterpenes, (7S)-p-cymene-2,7,8-triol (1) and (3R,4R,6S)-p-menth-1-ene-3,6,10-triol (2), were isolated from the fruits of Amomum kravanh. Their structures were established by spectroscopic data. The absolute configuration of the 7,8-diol moiety in 1 was assigned by CD data after addition of Mo2(OAc)4 in dimethyl sulfoxide (DMSO) solution. Compounds 1 and 2 exhibited weak activity of anti-platelet aggregation in vitro.

Keywords: Amomum kravanh; Zingiberaceae; monoterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amomum / chemistry*
  • Animals
  • Cymenes
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Fruit / chemistry*
  • Molecular Structure
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification*
  • Monoterpenes / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rabbits
  • Stereoisomerism
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • (3R,4R,6S)-p-menth-1-ene-3,6,10-triol
  • (7S)-p-cymene-2,7,8-triol
  • Cymenes
  • Drugs, Chinese Herbal
  • Monoterpenes
  • Platelet Aggregation Inhibitors
  • Terpenes
  • 4-cymene
  • p-menth-1-ene