Abstract
Two new monoterpenes, (7S)-p-cymene-2,7,8-triol (1) and (3R,4R,6S)-p-menth-1-ene-3,6,10-triol (2), were isolated from the fruits of Amomum kravanh. Their structures were established by spectroscopic data. The absolute configuration of the 7,8-diol moiety in 1 was assigned by CD data after addition of Mo2(OAc)4 in dimethyl sulfoxide (DMSO) solution. Compounds 1 and 2 exhibited weak activity of anti-platelet aggregation in vitro.
Keywords:
Amomum kravanh; Zingiberaceae; monoterpenes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amomum / chemistry*
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Animals
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Cymenes
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Fruit / chemistry*
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification*
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Monoterpenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
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Stereoisomerism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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(3R,4R,6S)-p-menth-1-ene-3,6,10-triol
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(7S)-p-cymene-2,7,8-triol
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Cymenes
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Drugs, Chinese Herbal
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Monoterpenes
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Platelet Aggregation Inhibitors
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Terpenes
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4-cymene
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p-menth-1-ene