Thrombosis, platelets, microparticles and PAH: more than a clot

Katie L Lannan; Richard P Phipps; R James White

doi:10.1016/j.drudis.2014.04.001

Thrombosis, platelets, microparticles and PAH: more than a clot

Drug Discov Today. 2014 Aug;19(8):1230-5. doi: 10.1016/j.drudis.2014.04.001. Epub 2014 Apr 18.

Authors

Katie L Lannan¹, Richard P Phipps², R James White³

Affiliations

¹ Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.
² Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Pathology and Laboratory Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.
³ Aab Cardiovascular Research Institute and Division of Pulmonary and Critical Care Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address: Jim_White@urmc.rochester.edu.

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Coagulation / physiology
Blood Platelets / pathology*
Cell-Derived Microparticles / pathology*
Humans
Hypertension, Pulmonary / pathology*
Platelet Activation / physiology
Thrombosis / pathology*

Abstract

Publication types

MeSH terms

Grants and funding