Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus

Mohamed-Elamir F Hegazy; Hisashi Matsuda; Seikou Nakamura; Taha A Hussein; Masayuki Yoshikawa; Paul W Paré

doi:10.1016/j.phytochem.2014.03.027

Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus

Phytochemistry. 2014 Jul:103:154-161. doi: 10.1016/j.phytochem.2014.03.027. Epub 2014 Apr 17.

Authors

Mohamed-Elamir F Hegazy¹, Hisashi Matsuda², Seikou Nakamura², Taha A Hussein³, Masayuki Yoshikawa², Paul W Paré⁴

Affiliations

¹ Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir St., Dokki, Giza 12622, Egypt.
² Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
³ Delta University for Science and Technology, Pharmacognosy Department, Faculty of Pharmacy, Gamasa, Egypt.
⁴ Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. Electronic address: paul.pare@ttu.edu.

PMID: 24746418
DOI: 10.1016/j.phytochem.2014.03.027

Abstract

Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded eight metabolites, in addition to eight other previously reported compounds, of which two were isolated for the first time as free acids. Structures were established by spectroscopic methods, including HREIMS, (1)H, (13)C, DEPT, (1)H-(1)H COSY, HMQC and HMBC NMR analysis. Antimicrobial activity against an array of common bacterial and fungal strains was measured via a colorimetric assay with minimal growth inhibition observed in the μg/mL range for one of the tested metabolites.

Keywords: Antimicrobial activity; Asteraceae; Chiliadenus montanus; Dioxane; Flavonoids; Sesquiterpenes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology*
Asteraceae / chemistry*
Herbal Medicine
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Plants, Medicinal

Substances

Anti-Bacterial Agents
Antifungal Agents