Objective: To explore the relationship of mid-trimester serum screening markers and adverse pregnancy outcomes.
Methods: We retrospectively reviewed all obstetric patients with mid-trimester screening data who delivered at our department from September 2010 to November 2012. Adjusted effects were estimated with Logistic regression analysis.
Results: A total of 3 618 cases were enrolled. The level of free β-subunit of human chorionic gonadotropin (fβ-hCG) [ ≥ 2.2 (multiple of median) MOM] was associated with the risk of pregnancy-related hypertension (OR = 2.06, 95%CI 1.18-3.60, P < 0.01). And fβ-hCG ( ≥ 2.2 MOM) and alpha-fetoprotein (AFP) ( ≥ 1.88 MOM) were associated with the development of placenta-related complications (P < 0.01, 0.05 respectively). Additionally, maternal weight was associated with the risk of pregnancy-related hypertension and placenta-related complications (both P < 0.05).
Conclusion: The mid-trimester screening markers fβ-hCG and AFP are associated the risk of adverse pregnancy outcomes. And their value may predict the risk of adverse pregnancy outcomes.