Preparation methods of alginate nanoparticles

Jerome P Paques; Erik van der Linden; Cees J M van Rijn; Leonard M C Sagis

doi:10.1016/j.cis.2014.03.009

Preparation methods of alginate nanoparticles

Adv Colloid Interface Sci. 2014 Jul:209:163-71. doi: 10.1016/j.cis.2014.03.009. Epub 2014 Mar 27.

Authors

Jerome P Paques¹, Erik van der Linden², Cees J M van Rijn³, Leonard M C Sagis⁴

Affiliations

¹ Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands; Laboratory of Physics and Physical Chemistry of Foods, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands.
² Laboratory of Physics and Physical Chemistry of Foods, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands.
³ Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands.
⁴ Laboratory of Physics and Physical Chemistry of Foods, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands. Electronic address: leonard.sagis@wur.nl.

PMID: 24745976
DOI: 10.1016/j.cis.2014.03.009

Abstract

This article reviews available methods for the formation of alginate nano-aggregates, nanocapsules and nanospheres. Primarily, alginate nanoparticles are being prepared by two methods. In the "complexation method", complex formation on the interface of an oil droplet is used to form alginate nanocapsules, and complex formation in an aqueous solution is used to form alginate nano-aggregates. In a second method w/o emulsification coupled with gelation of the alginate emulsion droplet can be used to form alginate nanospheres. We review advantages and disadvantages of these methods, and give an overview of the properties of the alginate particles produced with these methods.

Keywords: Alginate; Nano-aggregates; Nanobeads; Nanocapsules; Nanoparticles; Nanospheres.