How to grow a synapse

Christoph Straub; Bernardo L Sabatini

doi:10.1016/j.neuron.2014.03.033

How to grow a synapse

Neuron. 2014 Apr 16;82(2):256-7. doi: 10.1016/j.neuron.2014.03.033.

Authors

Christoph Straub¹, Bernardo L Sabatini²

Affiliations

¹ Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
² Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: bernardo_sabatini@hms.harvard.edu.

PMID: 24742454
DOI: 10.1016/j.neuron.2014.03.033

Abstract

Activity-dependent alterations in the strength of an individual glutamatergic synapse are often accompanied by changes in the size and shape of the postsynaptic terminal. Two studies in this issue of Neuron, Meyer et al. (2014) and Bosch et al. (2014), shed new light on the mechanisms and signaling pathways underlying structural long-term potentiation.

Publication types

Comment

MeSH terms

Animals
Dendritic Spines / physiology*
Hippocampus / cytology*
Humans
Long-Term Potentiation / physiology*
Neuronal Plasticity / physiology*
Neurons / cytology*
Neurons / physiology*
Neurons / ultrastructure*
Synapses / physiology*