Abstract
Systemic loxoscelism is a rare complication after Loxosceles reclusa (brown recluse spider) envenomation. Loxosceles venom contains pro-inflammatory proteins, which have been shown to be elevated in patients with hemophagocytic lymph histiocytosis. We present a case of a 10-year-old male that developed presumed systemic loxoscelism, secondary hemophagocytic lymphohistiocytosis with hepatic dysfunction and renal failure. He was treated with dexamethasone and made a full recovery.
MeSH terms
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Animals
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Brown Recluse Spider*
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Child
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Dexamethasone / therapeutic use
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Glucocorticoids / therapeutic use
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Hepatic Insufficiency / drug therapy
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Hepatic Insufficiency / etiology
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Hepatic Insufficiency / immunology*
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Hepatic Insufficiency / pathology
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Humans
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Insect Bites and Stings / complications
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Insect Bites and Stings / drug therapy
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Insect Bites and Stings / immunology*
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Insect Bites and Stings / pathology
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Lymphohistiocytosis, Hemophagocytic / drug therapy
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Lymphohistiocytosis, Hemophagocytic / etiology
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Lymphohistiocytosis, Hemophagocytic / immunology*
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Lymphohistiocytosis, Hemophagocytic / pathology
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Male
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Phosphoric Diester Hydrolases / immunology*
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Renal Insufficiency / drug therapy
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Renal Insufficiency / etiology
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Renal Insufficiency / immunology*
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Renal Insufficiency / pathology
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Spider Venoms / immunology*
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Treatment Outcome
Substances
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Glucocorticoids
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Spider Venoms
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loxosceles venom
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Dexamethasone
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Phosphoric Diester Hydrolases