Going forward with retromer

Ginny G Farias; David C Gershlick; Juan S Bonifacino

doi:10.1016/j.devcel.2014.03.018

Going forward with retromer

Dev Cell. 2014 Apr 14;29(1):3-4. doi: 10.1016/j.devcel.2014.03.018.

Authors

Ginny G Farias¹, David C Gershlick¹, Juan S Bonifacino²

Affiliations

¹ Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
² Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: bonifacinoj@helix.nih.gov.

Abstract

The retromer complex is well known to mediate retrograde transport from endosomes to the Golgi. In a recent issue of Neuron, Choy et al. (2014) identify a function for retromer in supporting fast, local delivery of neurotransmitter receptors from endosomes to the dendritic plasma membrane.

Publication types

Comment

MeSH terms

Animals
Cell Membrane / metabolism*
Dendrites / metabolism*
Endosomes / metabolism*
Multiprotein Complexes / metabolism*
Neurons / cytology*
Vesicular Transport Proteins / metabolism*

Substances

Multiprotein Complexes
Vesicular Transport Proteins

Grants and funding

ZIA HD001607-22/Intramural NIH HHS/United States