Optical imaging of brain activation in Gambian infants

Marie D Papademetriou; S Lloyd-Fox; N L Everdell; M K Darboe; S E Moore; A M Prentice; C E Elwell

doi:10.1007/978-1-4939-0620-8_35

Optical imaging of brain activation in Gambian infants

Adv Exp Med Biol. 2014:812:263-269. doi: 10.1007/978-1-4939-0620-8_35.

Authors

Marie D Papademetriou¹, S Lloyd-Fox², N L Everdell³, M K Darboe⁴, S E Moore^{4

5}, A M Prentice^{4

5}, C E Elwell³

Affiliations

¹ Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London, WC1E 6BT, UK. m.papademetriou@ucl.ac.uk.
² Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
³ Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London, WC1E 6BT, UK.
⁴ MRC International Nutrition Group, MRC Keneba, Keneba, The Gambia.
⁵ MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 24729242
DOI: 10.1007/978-1-4939-0620-8_35

Abstract

We used optical topography (OT) to investigate cognitive function in infants in rural Gambia. Images of changes in oxyhaemoglobin and deoxyhaemoglobin concentrations were reconstructed using a multispectral algorithm which uses the finite element method (FEM) to model the propagation of light through scattering tissue using the diffusion equation. High quality OT data enabled us to reconstruct images with robust representation of haemodynamic changes. OT is a feasible neuroimage technology for this resource-poor setting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Brain / physiology*
Finite Element Analysis
Gambia
Humans
Infant
Spectroscopy, Near-Infrared

Abstract

Publication types

MeSH terms

Grants and funding