Cyclometalated iridium(III)-β-carboline complexes as potent autophagy-inducing agents

Chem Commun (Camb). 2014 May 30;50(42):5611-4. doi: 10.1039/c4cc01461h.

Abstract

Two cyclometalated Ir(III)-β-carboline complexes were identified as potent inducers of autophagic cell death. Autophagy induced by these complexes is ROS-mediated and caspase-independent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Autophagy / drug effects*
  • Carbolines / chemistry*
  • Cell Line
  • Humans
  • Iridium / chemistry*
  • Ligands
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / pharmacology*

Substances

  • Alkaloids
  • Carbolines
  • Ligands
  • Organometallic Compounds
  • Iridium