Daylight-mediated photodynamic therapy in Spain: advantages and disadvantages

Abstract

Photodynamic therapy (PDT) is an option for the treatment of actinic keratosis, Bowen disease, and certain types of basal cell carcinoma. It is also used to treat various other types of skin condition, including inflammatory and infectious disorders. The main disadvantages of PDT are the time it takes to administer (both for the patient and for health professionals) and the pain associated with treatment. Daylight-mediated PDT has recently been reported to be an alternative to the conventional approach. Several studies have shown it to be similar in efficacy to and better tolerated than classic PDT for the treatment of mild to moderate actinic keratosis. Nevertheless, most of these studies are from northern Europe, and no data have been reported from southern Europe. The present article reviews the main studies published to date, presents the treatment protocol, and summarizes our experience with a group of treated patients.

Keywords: 5-aminolevulinic acid; Actinic keratosis; Daylight-mediated photodynamic therapy; Methylester of 5-aminolevulinic acid; Metiléster del ácido 5-aminolevulínico; Photodynamic therapy; Queratosis actínicas; Terapia fotodinámica; Terapia fotodinámica con luz de día; Tratamiento; Treatment; Ácido 5-aminolevulínico.